The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Chemical Formula: (C6H10O5)n 1.4. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Chemical Formula: (C6H10O5)n 1.4. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. EINECS #: 232-674-9 1.7. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Quantity: 1 700 kgs. No. Eur., JPE . Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Cellulose microcrystalline. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. ( Well-recognized product that can do it all. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. A family of polysaccharide products that allow distinctive drug delivery solutions. Material safety data sheet - FMC Corporation. In extrusion-spheronisation, it is the excipient of choice. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. endobj JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Packaging: 34 x 50 kgs fiber drums. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. %PDF-1.4 X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? <> MATERIAL SAFETY DATA SHEET Version: 1.0 1. 51395-75-6 Avicel RC 591. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. %PDF-1.4 (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. MCC helps in the formation of spheres because of its . G2W4de=u183KGH{ vQ#4:1\wc Are you sure you want to delete your template? More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. It is hygroscopic and insoluble in water. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. : 160182 Date Approved: 05/25/2010 Revision No. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Product Name: Microcrystalline Cellulose 1.2. Avicel Microcrystalline Cellulose Physical Properties. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. Revision No. However, it yields non-digestible fibre. Page 1 of 8. . \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. }o]X4]. Home. Origin(s): Plant/Botanical. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. endobj 5 0 obj PDF (28.38 mb) 2022 Corporate Fact Sheet. Gloves, eye protection and a dust mask should be used. Cellulose microcrystalline for column chromatography. %PDF-1.3 4 0 obj There may be more fiber in your food than you realized. . <> Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; It is available in different grades and particle sizes. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. ( Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. BIOACCUMULATIVE POTENTIAL The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . (Microcrystalline Cellulose Market Pr. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Production of Pharmaceutical Grade Microcrystalline Cellulose. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Revision No. l~5C Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. No. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). >> } !1AQa"q2#BR$3br Learn about FMC's differentiated biologically-based crop solutions. Microcrystalline Cellulose (MCC) Manufacturing Industry. Microcrystalline Cellulose; Cellulose; Functions. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Van Veen, G.K. Bolhuis, Y.S. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. The aqueous solution to barrier membrane coating. 1.3. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Buy Chemicals. It is, however, a good source of fibre. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. ( In large quantities it provides dietary bulk and may lead to a laxative effect. common form is used in vitamin supplements or tablets. Manufacturer: FMC BioPolymer. Hi, let us know if you have any questions as you visit our website. LOT #: Available upon request. The table below shows the most common physicochemical parameters of this raw material. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC stream No. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. Wu, K. Zuurman, H.W. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. 130. Quick Links. Thus, Avicel contributes no or very few calories to the food system. Are you looking for information about products and services by region? Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Medium size standard MCC grade, suited for the majority of directly compressible actives. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . undefined. Alginates also function as actives in some anti-reflux products. Earth Supplied Products LLC. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. X\o^ lH5JWy}DgKRR"Fs The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. SUBSTANCE IDENTIFICATION 1.1. endobj {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. The most. % endobj Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. By producing Avicel . (1962). on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Go to Investor Relations. JFIF ` ` ZExif MM * J Q Q Q C <> SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . Unique functionality for a broad range of pharmaceutical applications. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. 4 0 obj Document(s): certificate data msds. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Truly distinctive drug delivery solutions. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . : 9004-34-6 Date Approved: 01/31/2008 . gac74 [#B6`Wnw7 Product Name Cellulose microcrystalline. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Microcrystalline Cellulose NF. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. 9,LL!z It is a white, free-flowing powder. q9;v80q>jZ Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. Combines good flow and high compactibility. All rights reserved. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Millipore. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. No. Test Data Available. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Avicel PH-101. Report Category. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. PDF (4.11 mb) Footer menu 1. 1. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. PharmaCentral 2021 . pH 6.0 to 8.0 . SUBSTANCE IDENTIFICATION 1.1. . Request media, explore upcoming events and read our latest updates. Superior Performance: Provides excellent water uptake and rapid swelling . /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) . (&E. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. Watch Now. Microcrystalline Cellulose / Avicel PH-102. Powder becomes slippery when wet. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Product Name: Microcrystalline Cellulose E460 1.2. SDS - Safety Data Sheet. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. CAS #: 9004-34-6 . : 160182. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Browse Avicel PH-101 and related products at MilliporeSigma. Heavy metals, % NMT 0.001 bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Remove Explore how we work and why we apply science and creativity for a better world to everything we do. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Avicel PC 611 (FMC Biopolymer) . {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream FMC Corporation. };khd5x=fr Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Molecular weight: Not Applicable 1.5. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Created Date: 2/10/2020 8:51:41 PM . In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. <> The figure below illustrates the structural organisation of cellulose within plants. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. /Parent 3 0 R <> <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> Instead, they obtained a stable colloidal suspension. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. << In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. If breathing is difficult or if . >> Avicel PC 611 Microcrystalline Cellulose. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Avicel Microcrystalline Cellulose: Chemical Identifiers. /Resources 2 0 R At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. All Rights Reserved. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. endobj endobj cas:9032-51-3 msds CELLULOSE PAB. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Trademarks: Avicel PH-102. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. % : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Doses up to 30 g per day appear to be . 1 0 obj ( CAS 9004-34-6. 6 MSDS Ref. 1 0 obj Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. <> q9;v80 ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! q86@on$^X_HuH;3` Synonyms: Cellulose, Cellulose powder, Cotton linters. In 1964 FMC, Corporation . Avicel PH-200 microcrystalline cellulose NF, Ph. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. %PDF-1.5 Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Battista, O. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. 1.3. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. % Terms and Conditions Compliance Solutions Industries About 3E News & Events . An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. 0.25 - 0.37. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged.
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